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| Product Name | Thrombospondin-4, Recombinant, Mouse, aa27-963 (THBS4, TSP-4) |
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| Description | Purity ~90% (SDS-PAGE). Thrombospondin4 (TSP-4 ) is an ~140kD matricellular protein that is secreted as a disulfidelinked pentamer. Within the Thrombospondin family, TSP3 and TSP5/COMP are also pentameric, while TSP1 and TSP2 are trimeric. TSP4 regulates cellcell and cell matrix interactions and plays a role in cardiovascular physiology and neuronal development (1, 2). Mature mouse TSP-4 consists of an Nterminal heparinbinding domain, a coiled coil motif, four EGFlike repeats, seven TSP type3 repeats (one with an RGD motif), and a TSP Cterminal domain (2, 3). Mouse TSP-4 shares 93% and 97% amino acid sequence identity with human and rat TSP-4, respectively. TSP-4 binds a variety of matrix proteins including Collagens I, II, III, V, Laminin1, Fibronectin, and Matrilin2 (4). Interactions of TSP-4 with noncollagenous proteins are independent of divalent cations, whereas interactions with collagenous proteins are enhanced in the presence of zinc (4). TSP-4 binds to cell sur |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145841 |
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| Order / More Info | Thrombospondin-4, Recombinant, Mouse, aa27-963 (THBS4, TSP-4) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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