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| Product Name | TLR3, Recombinant, Human (Toll-like Receptor 3, CD283) |
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| Description | Purity ~95% (SDS-PAGE and HPLC). TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-kB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77kD glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain. Source: Recombinant protein corresponding to human TLR-3, expressed in 293 cells. Biological Activity: |
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| Size | 5ug, 25ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 149626 |
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| Order / More Info | TLR3, Recombinant, Human (Toll-like Receptor 3, CD283) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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