| 产品详情 |
| Edit |   |
|---|
| Product Name | CD5, Recombinant, Mouse, His-Tag (Leu-1, Ly-1, T1) |
|---|
| Description | Purity ~95% (SDS-PAGE). CD5, also known as Leu-1, Ly-1, and T1, is a 67kD transmembrane glycoprotein in the scavenger receptor superfamily (1). Mature mouse CD5 consists of a 347 amino acid (aa) extracellular domain (ECD) with three scavenger receptor cysteine-rich (SRCR) domains, a 30 aa transmembrane segment, and a 93aa cytoplasmic domain (2). Within the ECD, mouse CD5 shares 55% and 82% aa sequence identity with human and rat CD5, respectively. The 52kD ECD can be cleaved from the cell surface and circulates in the serum (3). CD5 has been shown to interact homophilically, with CD72 on B cells, and with beta-glucan components of fungal cell walls (4-6). CD5 expression on developing thymocytes is positively regulated by signaling through the T cell antigen receptor (TCR) and is up-regulated on tolerized peripheral CD4+ cells (7, 8). It inhibits TCR signaling and promotes T cell nonresponsiveness and survival (8-10). CD5 signaling inhibits the generation of regulatory T cells but promo |
|---|
| Size | 50ug |
|---|
| Concentration | n/a |
|---|
| Applications | ELISA |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | SwissProt: P13379 |
|---|
| Catalog # | 145779 |
|---|
| Price | |
|---|
| Order / More Info | CD5, Recombinant, Mouse, His-Tag (Leu-1, Ly-1, T1) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|