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| Product Name | Botulinum Neurotoxin, Type A, Light Chain, Recombinant, aa1-429 |
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| Description | Purity ~90% (Densitometry analysis). Clostridium botulinum neurotoxins (BoNT) are among the most toxic substances known to man. Seven immunologically distinct serotypes of neurotoxin, designated types A through G (BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G), have been identified. These neurotoxins are naturally produced complexed with one or more nontoxic neurotoxin-associated proteins (NAPs). NAPs are important to toxicity by ingestion in that they protect the neurotoxin from proteases, acidity, heat and they may also play a role in translocation across the mucosal layer. Synthesized as single 150kD polypeptide chains, the actual neurotoxin portion of the complex is subsequently activated by cleavage to produce two chains, a heavy chain and a light chain, which are linked by a single disulfide bond. For each toxin, the 50kD light chain is a zinc- dependent protease, which cleaves a single target protein essential for synaptic vesicle membrane fusion during neurotransmissio |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 215918 |
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| Order / More Info | Botulinum Neurotoxin, Type A, Light Chain, Recombinant, aa1-429 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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