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| Product Name | CD169/SIGLEC-1, BioAssay™ ELISA Kit (Human) (Sialoadhesin) |
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| Description | SIGLEC-1, also known as Sialoadhesin or CD169, is a cell adhesion molecule found on the surface of certain cells of the immune system called macrophages. This gene is mapped to 20p13. It belongs to the immunoglobulin superfamily(IgSF). Since sialoadhesin binds sialic acids with its N-terminal IgV-domain, it is also a member of the SIGLEC family. The localization and expression of SIGLEC-1 in humans has altered coincident with the evolutionary loss of Neu5Gc. SIGLEC-1-positive macrophages have a dual physiologic function. They act as innate 'flypaper' by preventing the systemic spread of lymph-borne pathogens and as critical gatekeepers at the lymph-tissue interface that facilitate the recognition of particulate antigens by B cells and initiate humoral immune responses. Sample Type: Cell culture supernates, serum and plasma (heparin, EDTA) Intended Use: For quantitative detection of human CD169 in cell culture supernates, serum and plasma (heparin, EDTA). Sensitivity: <10pg/ml Range: 15 |
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| Size | 96 tests |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 6614, SwissProt: Q9BZZ2 |
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| Catalog # | 352753 |
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| Order / More Info | CD169/SIGLEC-1, BioAssay™ ELISA Kit (Human) (Sialoadhesin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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