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| Product Name | NELL1, Recombinant, Mouse, aa17-810 (IDH3GL, Neural EGF-like like Protein 1) |
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| Description | Purity ~95% (SDS-PAGE). NELL1 (neural EGFlike like protein 1) is an ~140kD modular glycoprotein that plays an important role in bone physiology (1). NELL1 contains an Nterminal Laminin Glike domain and three vWF-C domains interspersed with five tandem EGFlike domains (2). Mature mouse NELL1 shares 98% and 93% aa identity with rat and human NELL1, respectively. NELL1 can be retained in the cytosol where it interacts with ARP3 (apoptosis-related protein 3) and becomes phosphorylated by PKC (3, 4). NELL1 is secreted as an ~400kD noncovalent homotrimer of heavily glycosylated subunits (5). It is expressed in bone and in select B cell lines (6, 7). NELL1 promotes the osteogenic differentiation of adiposederived stromal/stem cells and inhibits adipogenic differentiation (8). It does not promote osteoblastic differentiation from myoblasts, but it does enhance the activity of BMP2 in that function (9). NELL1 interacts directly with osteoblasts via Integrin alpha3beta1 (10, 11) and promot |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q2VWQ2 |
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| Catalog # | 145823 |
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| Order / More Info | NELL1, Recombinant, Mouse, aa17-810 (IDH3GL, Neural EGF-like like Protein 1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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