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| Product Name | Zap 70, active, Recombinant, Human (TCR Zeta Associated Protein kinase 70kD) |
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| Description | Purity ≥ 90% as determined by SDS-PAGE analysis. ZAP-70 is a non-receptor protein tyrosine kinase (part of the Syk/ZAP-70 family) that is involved in signaling by the T-cell antigen receptor (TCR). Ligation of the TCR/CD3 receptor in Jurkat T-cells induces phosphoprotein complexes which contain ZAP-70 (1). TCR zeta chains are initially phosphorylated by p56Lck that lead to recruitment of ZAP-70 via its SH2 domain. ZAP-70 in turn phosphorylates other proteins in the TCR-phosphoprotein complex. ZAP-70 is tyrosine phosphorylated in Jurkat T cells and in purified peripheral T cells after MHC-I ligation. Phosphorylation of ZAP-70 after MHC-I ligation is dependent on TCR/CD3 surface expression. Substrates for ZAP-70 include the zeta-chain dimer of the TCR/CD3 complex and LAT (linker for activation of T cells) (2). Direct tyrosine phosphorylation of LAT with activated ZAP-70 is necessary and sufficient for the association and activation of signaling proteins. ZAP-70 efficiently phosphorylates |
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| Size | 5ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | Z0300-10G |
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| Order / More Info | Zap 70, active, Recombinant, Human (TCR Zeta Associated Protein kinase 70kD) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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