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| Product Name | ATF2, Recombinant, Human, aa1-505, His-SUMO-Tag (Cyclic AMP-dependent Transcription Factor ATF-2) |
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| Description | Purity ~85% (SDS-PAGE). Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). In the nucleus, contributes to global transcription and the DNA damage response, in addition to specific transcriptional activities that are related to cell development, proliferation and death. In the cytoplasm, interacts with and perturbs HK1- and VDAC1-containing complexes at the mitochondrial outer membrane, thereby impairing mitochondrial membrane potential, inducing mitochondrial leakage and promoting cell death. The phosphorylated form (mediated by ATM) plays a role in the DNA damage response and is involved in the ionizing radiation (IR)-induced S phase checkpoint control and in the recruitment of the MRN complex into the IR-induced foci (IRIF). |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Activating transcription factor 2, Cyclic AMP-responsive element-binding protein 2, CREB-2, cAMP response element-binding protein CRE-BP1 |
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| Gene, Accession, CAS # | SwissProt: P15336 |
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| Catalog # | 372362 |
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| Order / More Info | ATF2, Recombinant, Human, aa1-505, His-SUMO-Tag (Cyclic AMP-dependent Transcription Factor ATF-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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