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| Product Name | AMG 319 |
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| Description | Purity >98%. AMG 319 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoform Delta (PI3KDelta; IC50 = 18 nM) that less effectively targets the Alpha, Beta, and Gamma isoforms (IC50 s = 33, 2.7, and 0.85 µM, respectively). It blocks anti-IgM/CD40L-induced proliferation (IC50 = 8.6 nM) and reduces Akt phosphorylation (IC50 = 1.5 nM) in B cells. AMG 319 is orally bioavailable and reduces inflammation in two animal models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 7-fluoro-aS-methyl-N-9H-purin-6-yl-2-(2-pyridinyl)-3-quinolinemethanamine |
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| Gene, Accession, CAS # | CAS: 1608125-21-8 |
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| Catalog # | LS-H6500 |
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| Price | |
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| Order / More Info | AMG 319 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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| 产品资料 |
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