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| Product Name | ATB-337 |
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| Description | Purity >98%. Hydrogen sulfide (H2 S) is a naturally occurring gasotransmitter with vasodilator and inflammatory modulating activity. Non-steroidal anti-inflammatory drugs (NSAIDs), such as indomethacin, diclofenac, and ibuprofen, are some of the most commonly used anti-inflammatory drugs available but exhibit significant side effects, particularly gastric damage, when used chronically. ATB-337 is a hybrid molecule of an H2 S donor and the NSAID diclofenac. In rats, diclofenac at 10-50 µmol/kg caused significant gastrointestinal damage, whereas no damage was observed with ATB-337 treatment at the same dose. ATB-337 at 50 µmol/kg does not promote leukocyte adherence to vascular endothelium, an effect observed with diclofenac treatment alone. COX-1 and COX-2 were inhibited with similar efficacy by diclofenac and ABT-337. An increase in expression of the pro-inflammatory mediator TNF-Alpha, as well as, the adhesion molecules ICAM-1 and LFA-1 were not observed in rats treated with 50 µmol/kg ABT-337, effects seen with equimolar doses of diclofenac. These results indicate that H2 S-releasing derivatives of NSAIDs may prove to be more effective anti-inflammatory agents than traditional NSAIDs alone. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-[(2,6-dichlorophenyl)amino]-benzeneacetic acid, 4-(3-thioxo-3H-1,2-dithiol-5-yl)phenyl ester, ACS 15, S-Diclofenac |
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| Gene, Accession, CAS # | CAS: 912758-00-0 |
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| Catalog # | LS-H6655 |
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| Order / More Info | ATB-337 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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