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| Product Name | GDF-3, Recombinant, Human, Animal Free (Growth/Differentiation Factor-3, Vgr-2) |
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| Description | Purity ~98% (SDS-PAGE gel, HPLC). GDF-3 is a member of the TGF-beta superfamily of growth and differentiation factors, and is highly homologous to GDF-9.Unlike most TGF-beta family members, GDF-3 and GDF-9 are not disulfide-linked dimers.GDF-3 is expressed in adult bone marrow, spleen, thymus, and adipose tissue.The expression of GDF-3 is upregulated in high-fat-fed wild-type FABP4/aP2 null mice and was associated with obesity, but not with the related hyperglycemia/hyperinsulinemia which characterizes Type 2 diabetes.Recombinant human GDF-3 is a 26.0kD non-disulfide-linked homodimer containing two 114 amino acid polypeptide chains. Source: Recombinant protein corresponding to human GDF-3 expressed in E. coli. Biological Activity: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 100-150ng/ml. AA Sequence: AAIPVPKLSC KNLCHRHQLF INFRDLGWHK WIIAPKGFMA NYCHGECPFS LTISLNSSNY AFMQALMHAV DPEIPQAVCI PTKLSPISM |
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| Size | 5ug, 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Growth/Differentiation Factor-3, Vgr-2 |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 208623 |
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| Order / More Info | GDF-3, Recombinant, Human, Animal Free (Growth/Differentiation Factor-3, Vgr-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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