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| Product Name | GDF-11, Recombinant, Human (Growth/Differentiation Factor-11, BMP-11) |
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| Description | Purity ~98% (SDS-PAGE). GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves arrest of progenitor cell cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their aa sequence, suggests that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant human GDF-11 is a 25kD disulfide-linked homodimer containing two 109aa polypeptide chains. Source: Recombinant protein corresponding to human GDF-11, expressed in E. coli. Biological Activity: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The ED50 for this effect is 0.08-0.10ug/ml. Endotoxin: <0.1ng/ug of protein (<1EU/ug) AA Sequence: NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYF |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | GDF11, Gene ID: 10220, Accession: O95390 |
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| Catalog # | 219787 |
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| Order / More Info | GDF-11, Recombinant, Human (Growth/Differentiation Factor-11, BMP-11) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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