| 产品详情 |
| Edit |   |
|---|
| Product Name | GDF5, Recombinant Mouse, aa376-495, His-Tag (Growth/differentiation Factor 5) |
|---|
| Description | Purity ~90% (SDS-PAGE). Growth factor involved in bone and cartilage formation. During cartilage development regulates differentiation of chondrogenic tissue through two pathways. Firstly, positively regulates differentiation of chondrogenic tissue through its binding of high affinity with BMPR1B and of less affinity with BMPR1A, leading to induction of SMAD1-SMAD5-SMAD8 complex phosphorylation and then SMAD protein signaling transduction. Secondly, negatively regulates chondrogenic differentiation through its interaction with NOG. Required to prevent excessive muscle loss upon denervation. This function requires SMAD4 and is mediated by phosphorylated SMAD1/5/8. Binds bacterial lipopolysaccharide (LPS) and mediates LPS-induced inflammatory response, including TNF secretion by monocytes. Source: Recombinant protein corresponding to aa376-495 from mouse GDF5, fused to His-Tag at N-terminal, expressed in E. coli. Molecular Weight: ~17.6kD AA |
|---|
| Size | 10ug, 50ug, 100ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | Bone morphogenetic protein 14, BMP-14 |
|---|
| Gene, Accession, CAS # | SwissProt: P43027 |
|---|
| Catalog # | 373417 |
|---|
| Price | |
|---|
| Order / More Info | GDF5, Recombinant Mouse, aa376-495, His-Tag (Growth/differentiation Factor 5) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|