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| Product Name | Integrin alpha 6 beta 1, CF, Recombinant, Human, aa24-1012 |
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| Description | Purity ~95% (SDS-PAGE). Integrin alpha6beta1, also called platelet glycoprotein GPIcIIa, is a laminin binding integrin that is expressed on T cells, monocytes, endothelial cells, stem cells, and platelets (1-9). The noncovalent heterodimer is composed of ~150kD alpha6/CD49f and 130kD beta1/CD29 type I transmembrane glycoprotein subunits (2). While alpha6 pairs only with beta1 or beta4, twelve integrins share the beta1 subunit (1-5). The alpha6 subunit is cleaved into extracellular heavy and transmembrane light chains (3). Alternative splicing in the human alpha6 extracellular domain (ECD) at amino acid (aa) 216 creates X1 (ubiquitous), X2 and X1X2 isoforms, while splicing at a mouse or human cytoplasmic site creates A and B isoforms (10, 11). These forms do not appear to alter the binding specificity (4, 10, 11). The beta1 ECD contains a vWFA domain, which participates in binding. Each subunit then has a transmembrane sequence and a short cytoplasmic tail. The dimer is folded when it |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Integrin alpha 6 beta 1, CF, Recombinant, Human, aa24-1012 (Platelet Glycoprotein GPIc-IIa, Integrin Alpha6beta1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145810 |
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| Order / More Info | Integrin alpha 6 beta 1, CF, Recombinant, Human, aa24-1012 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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