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| Product Name | Integrin alpha 7 beta 1, Recombinant, Mouse, aa34-1033 (VLA-7, Very Late Antigen-7) |
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| Description | Purity ~95% (SDS-PAGE). Integrin alpha7beta1, also called VLA-7 (very late antigen7), is the major lamininbinding integrin in cardiac and skeletal muscle (1-4). The non-covalent heterodimer is composed of ~150kD alpha7 and 130kD beta1/CD29 type I transmembrane glycoprotein subunits with short cytoplasmic tails (2). While alpha7 pairs only with beta1, twelve integrins share the beta1 subunit (1-5). The longest version of alpha7 is the X1X2B form, encoding 1179 amino acids (aa). Six alternatively spliced 1116-1160aa isoforms of the alpha7 subunits have short extracellular (X1, X2) or cytoplasmic (A, C) deletions. Isoforms are differentially expressed by tissue and developmental stage and may show preferences for specific laminins (35). The beta1 vWFA domain participates with the alpha7 FGGAP motifs in ligand binding. The alpha7 subunit is cleaved into extracellular heavy and transmembrane/cytoplasmic light chains (3). The mouse alpha7 heavy chain shares 89%, 90%, 87% and 85% aa seque |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 145812 |
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| Order / More Info | Integrin alpha 7 beta 1, Recombinant, Mouse, aa34-1033 (VLA-7, Very Late Antigen-7) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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