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| Product Name | PDE10A Inhibitor, Cpd15 |
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| Description | Purity ~98% (HPLC). A cell-permeable pyrazoloquinoline compound that acts as a potent phosphodiesterase 10A inhibitor (Ki≤5nM against human PDE10A), while exhibiting >500-fold selectivity over other human PDEs 1-11 and little activity against CYP3A4 (IC50 >20uM) or a panel of 23 kinases (IC50 >30uM). Reported to be orally available in monkey and rat species and be efficacious in reversingnMDAR antagonist (+)-MK-801-induced hyperactivity in a ratsl (MED = 10mg/kg p.o.) in vivo. Solubility: DMSO Molar Mass: 353.81 Primary Target Ki: ≤5nM |
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| Size | 5mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | PDE10A Inhibitor, Cpd15 (Phosphodiesterase 10A Inhibitor, (6-chloro-3,8-dimethyl-1H-pyrazolo[3,4-b]quinolin-4-yl)(2-methylpyrimidin-5-yl)methanol) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217627 |
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| Price | |
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| Order / More Info | PDE10A Inhibitor, Cpd15 from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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