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| Product Name | BCMA IgG2a Fc, Fusion Protein (B Cell Maturation Protein) (Biotin) |
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| Description | Purified by Protein A affinity chromatography. The human B cell activating factor (BAFF) and APRIL(a proliferation inducing ligand) are both type II molecules belonging to the TNF superfamily. They are expressed by non-B cells, and are down-regulated by mitogenic stimulation.2 BAFF and APRIL bind to at least two receptors: TACI (transmembrane activator and CAML-interactor) and BCMA (B cell maturation antigen), both of which are restricted to B cells.3,4 Ligation of these receptors with recombinant BAFF dramatically increases IgM production by peripheral blood B cells 1. Recently a third receptor for BAFF (BAFF-R) was described.5 Cell surface BAFF can be cleaved to form a soluble trimeric molecule. 2BCMA-muIg binds to recombinant BAFF-muCD8 and can inhibit binding of this molecule to receptors on Raji cells. Molecular Structure: A soluble molecule consisting of the extracellular (54aa) domain of human BCMA fused to the murine IgG2a Fc (232 aa). Predicted monomeric weight: 33kD. Transfec |
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| Size | 25ug |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | B0807-50C |
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| Order / More Info | BCMA IgG2a Fc, Fusion Protein (B Cell Maturation Protein) (Biotin) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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