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| Product Name | Cyclophilin B, Recombinant, Human (PPIB, Peptidyl prolyl isomerase B, CYPB; SCYLP; CYP-S1) |
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| Description | Purity ~95% (SDS-PAGE). Cyclophilin B is a cyclosporine-binding protein. It is both secreted and retained in the ER. When secreted, Cyclophilin B mediates chemotaxis and T cell adhesion to fibronectin. This is likely due to its prolyl cis/trans isomerase activity. Intracellularly, Cyclophilin B appears to serve as a molecular chaperone for molecules destined for secretion. It does so via stabilization, and facilitating the activity of additional chaperones. It also bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Source: Recombinant protein corresponding to human Cyclophilin B, expressed in E. coli. Molecular Weight: ~21.2kD Specific Activity: >220 nmoles/min/mg Endotoxin: <1.0EU/1ug of protein (determined by LAL method) AA Sequence: MLLPGPSAAD EKKKGPKVTV KVYFDLRIGD EDVGRVIFGL FGKTVPKTVD NFVALATGEK GFGYKNSKFH RVIKDFMIQG GDFTRGDGTG GKSIYGERFP DENFKLKHYG PGWVSMANAG KDTNGSQFFI TTVKTAWLDG KHVVFGKVLE GMEVVRKVES TKTDSRDKPL KDVIIADCG |
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| Size | 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | Gene ID: 5479, SwissProt: P23284 |
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| Catalog # | 169947 |
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| Order / More Info | Cyclophilin B, Recombinant, Human (PPIB, Peptidyl prolyl isomerase B, CYPB; SCYLP; CYP-S1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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