| 产品详情 |
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| Product Name | NFkB Activating Kinase, CT, Blocking Peptide |
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| Description | Purified 60-70%. Synthetic peptide (ERFGSLTMDGGLRNVD) corresponding to amino acids 712 to 727 of human NAK/TBK1 (1,2), which are identical to those of mouse homologue (1). Nuclear factor kappa B (NF-kB) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and in?ammatory responses. NF-kB mediates the expression of a great variety of genes in response to extracellular stimuli. NF-kB is associated with IkB proteins in the cell cytoplasm, which inhibit NF-kB activity. Phosphorylation of I-kB by IkB kinase (IKK) complex leads to degradation of I-kB and activation of NF-kB. The IKK complex contains IKKa, IKKb, and IKKg. A novel IKK related kinase was recently identi?ed and designated TBK1 (TANK-binding kinase 1), NAK (NF-kB-activating kinase), and T2K (1-3). NAK/TBK1 activates IKKb through direct phosphorylation. NAK/TBK1 is activated by growth factors and PMA and mediates IKK and NF-kB activation in response to growth factors (2). NA |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | ELISA WB |
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| Other Names | NFkB Activating Kinase, CT, Blocking Peptide (Nuclear Factor kappa B, NAK, TBK1, TANK-Binding Kinase 1) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | N2301-40P |
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| Order / More Info | NFkB Activating Kinase, CT, Blocking Peptide from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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