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| Product Name | RANKL, aa85-245, Recombinant, Human |
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| Description | Purity ~90% (SDS-PAGE). RANK L, is a 39-45kD type II transmembrane (TM) protein in the tumor necrosis factor family, designated TNFSF11 (1-5). RANK L, produced by osteoblasts and bone marrow stromal cells, is required for differentiation of osteoclasts and stimulates bone resorption (4, 6). It is also produced by activated T cells and augments dendritic cell stimulation; RANK L-/- mice lack lymph nodes and have impaired thymocyte development (1-3, 6). The human RANK L cDNA encodes 317aa, including a 47aa cytoplasmic domain, a 21aa TM region, and a 249aa extracellular domain (ECD) with two potential N-linked glycosylation sites (note: aa85-245 of Accession # AAC51762 is identical to aa157-317 of SwissProt # O14788. This aa range contains the ECD trimerization and receptor-binding motifs, but not ECD proteolytic cleavage sites). Within the ECD, human RANK L shares 89%, 89%, 93% and 95% aa identity with mouse, rat, bovine and porcine RANK L, respectively. Mouse RANK L can stimulate human |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RANKL, aa85-245, Recombinant, Human (Receptor Activator of Nuclear Factor kappa B Ligand, Receptor Activator of NFkB Ligand, CD254, hRANKL2, hRANKL-2, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL, sOdf, SOFA, TNF-related Activation-induced Cytokine, TRANCE, Tumor Necrosis Factor Ligand Superfamily Member 11, Tumor Necrosis Factor Superfamily Member 11, TNFSF11) |
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| Gene, Accession, CAS # | Accession: AAC51762 |
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| Catalog # | R1075-10U |
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| Order / More Info | RANKL, aa85-245, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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