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| Product Name | RANKL, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). Human RANKL is a member of the tumor necrosis factor superfamily. It primarily affects the immune system by controlling bone regeneration and remodeling. It functions in osteoclast differentiation and activation. It also is expressed by T helper cells as a factor in dendritic cell maturation and survival. It is expressed after T-cell activation. It also appears to have a role in the regulation of apoptosis through activation of the antiapoptotic kinase AKT/PKB. It is not only expressed by immune cells, but also on a number of other cells in the lung, thymus, skeletal muscle and many others. It can be expressed as a trimeric transmembrane protein, a secreted form or a truncated ectodomain. Human RANKL shares 85% sequence similarity with mouse RANKL. Source: Recombinant protein corresponding to human RANKL expressed in E. coli. Molecular Weight: ~20kD Endotoxin: <1EU/ug (LAL) |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | RANKL, Recombinant, Human (TNFSF11, Soluble Receptor Activator of NFkB Ligand, TRANCE, TNF-Related Activation-Induced Cytokine, OPGL, ODF, Osteoclast Differentiation Factor) |
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| Gene, Accession, CAS # | SwissProt: O14788 |
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| Catalog # | 500418 |
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| Order / More Info | RANKL, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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