| 产品详情 |
| Edit |   |
|---|
| Product Name | RANKL, Recombinant, Human (hRANKL, RANKL, TRANCE, TNFSF11) (Carrier free) |
|---|
| Description | Purity ~98% (SDS-PAGE). RANKL, also known as TRANCE or OPGL, is a member of the TNF superfamily of ligands. T cells, mammary epithelial cells, and endothelial cells can produce RANKL (1). RANKL is expressed as a type II transmembrane protein or cleaved into a soluble form by extracellular proteases, such as TACE, ADAM10, and matrix metalloproteases (1). Alternative splicing also results in the production of soluble RANKL (1). RANKL signaling is antagonized by osteoprotegerin, which functions as a soluble decoy receptor (2). RANKL plays key roles in mammary gland development and dendritic cell survival and is required for osteoclast differentiation and survival (3-6). Research studies have shown that RANKL deficiencies in both mice and humans are associated with abnormally increased bone density and defects in lymphoid organogenesis (5,6). Source: Recombinant protein corresponding to human RANKL expressed in 293 cells. Molecular Weight: ~20.484kD Endotoxin: <0.01ng/1ug Bioactivity: Dete |
|---|
| Size | 10ug |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession, CAS # | Gene ID: 8600, SwissProt: O14788 |
|---|
| Catalog # | 137485 |
|---|
| Price | |
|---|
| Order / More Info | RANKL, Recombinant, Human (hRANKL, RANKL, TRANCE, TNFSF11) (Carrier free) from UNITED STATES BIOLOGICAL |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|