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| Product Name | Rankl, Soluble, Recombinant, Rat |
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| Description | Purity ≥98% by SDS-PAGE gel and HPLC analyses. RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naive T-cell proliferation in a mixed lymphocyte reaction, to promote the survival of RANK + T cells, and to regulate T-cell-dependent immune response. RANKL, which is expressed in a variety of cells including osteoblasts, fibroblasts, activated T-cells and bone marrow stromal cells, is also capable of interacting with a decoy receptor called OPG. Binding of soluble OPG to sRANKL inhibits osteoclastogenesis by interrupting the signaling between stromal cells and osteoclastic progenitor cells, thereby leading to excess accumulation of bone and cartilage. Recombinant rat sRANKL is a 19.4kD polypeptide comprising the TNF h |
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| Size | 2ug, 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Rankl, Soluble, Recombinant, Rat (Tumor Necrosis Factor Ligand Superfamily Member 11, Osteoclast Differentiation Factor, ODF, Osteoprotegerin Ligand, OPGL, Receptor Activator of Nuclear Factor kappa-B Ligand, RANKL, TNF-related Activation-induced Cytokine, TRANCE, CD254, Tnfsf11, Opgl, Trance) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 143509 |
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| Order / More Info | Rankl, Soluble, Recombinant, Rat from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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