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| Product Name | Mcr1, Recombinant, E. coli, aa1-541, His-SUMO-Tag (Probable Phosphatidylethanolamine Transferase Mcr-1) |
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| Description | Purity ~90% (SDS-PAGE). Probably catalyzes the addition of a phosphoethanolamine moiety to lipid A. Phosphoethanolamine modification of lipid A gives polymyxin resistance (PubMed:26603172).1 Publication Confers resistance to polymyxin-type antibiotics; expression of the Mcr-1 protein in E. coli increases colistin and polymyxin B minimal inhibitory concentration (MIC) from 0.5mg/ml to 2mg/ml. The pHNSHP45 plasmid can transfer efficiently (0.1 to 0.001) to other E.coli strains by conjugation and increases polymxin MIC by 8- to 16-fold; it may not require selective pressure to be maintained in the cell. When transformed into K.pneumoniae or P.aeruginosa it also increases polymxin MIC 8- to 16-fold. In a murine (BALB/c mice) thigh infection study using an mcr1-encoding plasmid isolated from a human patient, the plasmid confers in vivo protection against colistin (PubMed:26603172). Source: Recombinant protein corresponding to aa1-541 from E. coli Mcr1, fused to His-SUMO-Tag at N-terminal, expressed in E. coli. Mol |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Polymyxin resistance protein MCR-1 |
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| Gene, Accession, CAS # | SwissProt: A0A0R6L508 |
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| Catalog # | 374169 |
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| Order / More Info | Mcr1, Recombinant, E. coli, aa1-541, His-SUMO-Tag (Probable Phosphatidylethanolamine Transferase Mcr-1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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