| 产品详情 |
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| Product Name | g-Secretase Inhibitor XX |
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| Description | Purity ~95% (HPLC). A cell-permeable dibenzazepine (dbz) compound that acts as a potent y-secretase inhibitor and significantly lowers both brain and plasma AB40 levels by ~72% in Tg2576 mutant APP transgenic mouse model (100umol/kg, b.i.d). Induces a heterogeneous reorganization of the crypt structural-proliferative units in the intestinal tract and of the stem cell niche in the colon. Also potently inhibits Notch processing (IC50=1.7nM in SupT1 cells) and induces conversion of proliferative crypt cells to post-mitotic goblet cells in both the C57BL/6 and ApcMin mouse models (10umol/kg, i.p). Formula: C26H23F2N3O3 Primary Target: g-secretase Secondary Target: Notch processing (IC50 = 1.7nM in SupT1 cells) Solubility: DMSO Molecular Weight: 463.4 |
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| Size | 500ug, 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | g-Secretase Inhibitor XX ((S,S)-2-[2-(3,5-Difluorophenyl)acetylamino]-N-(5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl)propionamide, DBZ, Dibenzazepine) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217372 |
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| Order / More Info | g-Secretase Inhibitor XX from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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