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| Product Name | PSAP, Recombinant, Human, aa311-391, GST-Tag (Proactivator Polypeptide) |
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| Description | Purity ~90% (SDS-PAGE). Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. Source: Recombinant protein corresponding to aa311-391 |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Proactivator polypeptide |
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| Gene, Accession, CAS # | SwissProt: P07602 |
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| Catalog # | 374896 |
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| Order / More Info | PSAP, Recombinant, Human, aa311-391, GST-Tag (Proactivator Polypeptide) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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