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| Product Name | TXNRD1, SelCys498Cys, Recombinant, Human |
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| Description | Purity ~95% (SDS-PAGE). The mammalian thioredoxin reductases (TrxRs) are a family of selenocysteine-containing pyridine nucleotide-disulfide oxido-reductases. All the mammalian TrxRs are homologous to glutathione reductase with respect to primary structure including the conserved redox catalytic site (-Cys-Val-Asn-Val-Gly-Cys-) but distinctively with a C-terminal extension containing a catalytically active penultimate selenocysteine (SeCys) residue in the conserved sequence (-Gly-Cys-SeCys-Gly). TrxR is homodimeric protein in which each monomer includes an FAD prosthetic group, a NADPH binding site and a redox catalytic site. Electrons are transferred from NADPH via FAD and the active-site disulfide to C-terminal SeCys-containing redox center, which then reduces the substrate like thioredoxin. The members of TrxR family are 55-58kD in molecular size and composed of three isoforms including cytosolic TrxR1, mitochondrial TrxR2, and TrxR3, known as Trx and GSSG reductase (TGR). TrxR play |
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| Size | 500ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | TXNRD1, SelCys498Cys, Recombinant, Human (Thioredoxin Reductase 1, Cytoplasmic, TR, Gene Associated with Retinoic and Interferon-induced Mortality 12 Protein, GRIM-12, Gene Associated with Retinoic and IFN-induced Mortality 12 Protein, KM-102-derived Reductase-like Factor, Thioredoxin Reductase TR1, GRIM12, KDRF) |
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| Gene, Accession, CAS # | SwissProt: P10599 |
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| Catalog # | T5010-14M |
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| Price | |
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| Order / More Info | TXNRD1, SelCys498Cys, Recombinant, Human from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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