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| Product Name | Recombinant Human Tumor necrosis factor ligand superfamily member 12 |
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| Description | 43-149aa; Extracellular Domain. MW: 38.85kD. Purity >90% as determined by SDS-PAGE. Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
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| Size | 0.01 mg (E-Coli), 0.05 mg (E-Coli), 0.1 mg (E-Coli), 0.2 mg (E-Coli), 0.5 mg (E-Coli) |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | [APO3 ligand; TNF-related weak inducer of apoptosis; TWEAK] |
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| Gene, Accession, CAS # | TNFSF12, Gene ID: 8742, Accession: NP_003800.1 |
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| Catalog # | MBS1136538 |
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| Order / More Info | Recombinant Human Tumor necrosis factor ligand superfamily member 12 from MYBIOSOURCE INC. |
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| Product Specific References | TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis.Chicheportiche Y., Bourdon P.R., Xu H., Hsu Y.-M., Scott H., Hession C., Garcia I., Browning J.L.J. Biol. Chem. 272:32401-32410(1997) Identification of a ligand for the death-domain-containing receptor Apo3.Marsters S.A., Sheridan J.P., Pitti R.M., Brush J., Goddard A., Ashkenazi A.Curr. Biol. 8:525-528(1998) An endogenous hybrid mRNA encodes TWE-PRIL, a functional cell surface TWEAK-APRIL fusion prote |
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