| 产品详情 |
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| Product Name | FLRG, Human, BioAssay™ ELISA Kit |
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| Description | Follistatin-related Gene (FLRG), also known as Follistatin-like 3 (FSTL3) and Follistatin-related protein (FSRP), is a 30-35kD secreted glycoprotein that exerts a broad range of activities by neutralizing Activin A and Myostatin function. Mature human FLRG consists of an Activin and Myostatin binding N-terminal domain, two Follistatin-like domains, and two Kazal-like domains. BMP-2, -6, and -7 do not compete for Activin A binding, and FLRG binds only weakly to Activin B. Unlike Follistatin, FLRG does not contain a heparin-binding domain and does not interact with heparan sulfate proteoglycans. A short form of FLRG, which lacks the signal sequence and is found in the nucleus, retains Activin-blocking capability. Nuclear FLRG binds to the transcription factor AF10, induces AF10 homo-oligomerization, and enhances AF10-dependent gene transcription. Mature human FLRG shares 84% aa sequence identity with mouse and rat FLRG. FLRG expression is induced by Activin A, providing negative feedback |
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| Size | 1 kit |
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| Concentration | n/a |
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| Applications | ELISA |
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| Other Names | FLRG, Human, BioAssay™ ELISA Kit (Follistatin-related Protein 3, Follistatin-like Protein 3, Follistatin-related Gene Protein, FSTL3, UNQ674/PRO1308) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | F9090-05 |
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| Order / More Info | FLRG, Human, BioAssay™ ELISA Kit from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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