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| Product Name | Txnip, Recombinant, Mouse, aa1-397, His-Tag (Thioredoxin-interacting Protein) |
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| Description | Purity ~90% (SDS-PAGE). May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1). Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Source: Recombinant protein corresponding to aa1-397 from mouse Thioredoxin-interacting Protein, fused to His-Tag at N-terminal, expressed in Yeast. Molecular Weight: ~46.4kD AA |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Vitamin D3 up-regulated protein 1 |
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| Gene, Accession, CAS # | SwissProt: Q8BG60 |
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| Catalog # | 375732 |
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| Order / More Info | Txnip, Recombinant, Mouse, aa1-397, His-Tag (Thioredoxin-interacting Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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