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| Product Name | Capillary Morphogenesis Gene 2, Recombinant, Mouse (CMG-2, Anthrax Toxin Receptor 2, ANTXR2) |
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| Description | Purity ≥ 95%, as determined by SDS-PAGE and visualized by silver stain. Capillary Morphogenesis Gene-2 (CMG-2) is a widely expressed anthrax toxin receptor (ATR) family protein (1-4). CMG-2 is a ~55 kD protein that contains a 31 amino acid (aa) signal sequence, a 287 aa extracellular domain (ECD), a 21 aa transmembrane sequence, and a 148 aa cytoplasmic domain. Unlike human CMG-2 which has four isoforms, only one sequence has been reported for mouse CMG-2. The main functional domain of CMG-2 is an extracellular integrin-like von Willebrand factor type A (VWA) domain with a metal ion dependent adhesion site (MIDAS), through which it adheres selectively to collagen type IV and laminin (1-6). CMG-2 isoform 2 is induced in HUVEC as they undergo capillary formation in collagen matrices in vitro (4). In humans, CMG-2 is mutated in juvenile hyaline fibromatosis and infantile systemic hyalinosis disorders, and several of these mutations result in loss of laminin binding (7). CMG-2 and the rela |
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| Size | 50ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q6DFX2 |
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| Catalog # | C1077-45A |
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| Order / More Info | Capillary Morphogenesis Gene 2, Recombinant, Mouse (CMG-2, Anthrax Toxin Receptor 2, ANTXR2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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