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| Product Name | Agomelatine |
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| Description | Purity >98%. Melatonin, produced in the pineal gland, is an endogenous regulator of circadian rhythms. It acts through the melatonin receptors (MT1 and MT2) and has been shown to have anti-depressant activity in experimental models of clinical depression. Agomelatine is a metabolically stable analog of melatonin that displays agonist activity for MT1 and MT2 binding with nanomolar affinity. However, unlike melatonin, agomelatine is a competitive antagonist of human and porcine serotonin (5-HT2C ) receptors (pKi = 6.2 and 6.4, respectively) as well as human 5-HT2B receptors (pKi = 6.6). Agomelatine abolishes 5-HT2C agonist effects both in cells and in vivo . It also dose-dependently increases extracellular levels of noradrenaline and dopamine in frontal cortex of freely moving rats. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-[2-(7-methoxy-1-naphthalenyl)ethyl]-acetamide, Valdoxan® |
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| Gene, Accession, CAS # | CAS: 138112-76-2 |
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| Catalog # | LS-H6455 |
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| Order / More Info | Agomelatine from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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