| 产品详情 |
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| Product Name | Dafadine-A |
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| Description | Purity ~98% (HPLC). A cell-permeable isoxazoloamide compound that specifically inhibits DAF-9 activity in C. elegans (~20uM) without affecting the activity of DAF-12 and sterol- and oxysterol-metabolizing P450s. Reversibly targets the catalytic heme iron of DAF-9 cytochrome p450 and induce a constitutive dauer (Daf-c), distal-tip cell migration (Mig) and protruding vulval (Pvl) phenotypes in wild-type C.elegans (at ~25uM). Also, shown to be one of the most potent inhibitors of CYP27A1, the mammalian ortholog of DAF-9. Robustly promotes dauer formation (non-aging stress-resistant alternative third larval stage) only in wild type C. elegans and extends their life span by about 29%. Formula: C23H25N3O3 Solubility: DMSO Molar Mass: 391.5 |
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| Size | 25mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | Dafadine-A ((5-((2,6-Dimethylphenoxy)methyl)isoxazol-3-yl)(4-(pyridin-4-yl)piperidin-1-yl)methanone, 4-(1-((5-((2,6-Dimethylphenoxy)methyl)-3-isoxazolyl)carbonyl)-4-piperidinyl)pyridine, DAF-9 Cytochrome P450 Inhibitor, Dafadine-A) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217310 |
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| Order / More Info | Dafadine-A from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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