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| Product Name | CYR61, Recombinant, Human (Cysteine-rich Angiogenic Inducer 61, CCN1, G1G1 Protein) |
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| Description | Purity ~95% (SDS-PAGE). CYR61 is a member of the CCN family of secreted cysteine rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK). Source: Recombinant protein corresponding to 357aa residues from human CYR61, expressed in E. coli. Molecular Weight: ~39.4kD Biological Activity: Determined by the dose-dependent stimulation of the proliferation of mouse 3T3 cells. The expected ED50 f |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | CCN1, G1G1 protein |
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| Gene, Accession, CAS # | CYR61, Gene ID: 3491, Accession: O00622 |
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| Catalog # | 219677 |
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| Order / More Info | CYR61, Recombinant, Human (Cysteine-rich Angiogenic Inducer 61, CCN1, G1G1 Protein) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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