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| Product Name | IL-28A, Recombinant, Human (Interleukin-28A, IFN lambda 2) |
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| Description | Purity ~95% (SDS-PAGE). IL-28A is distantly related to type I interferons and the IL-10 family. Expression of IL-28A is induced by viral infection which interacts with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor alpha. IL-28A exhibits common features with type I IFNs such as antiviral activity, antiproliferative activity and in vivo antitumor activity. IL-28A acts similarly to IFNs, but is less effective generally and has activity in a more limited range of cell lines. IL-28A induces ELR(-) CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-gamma-independent manner. IL-28A produced in response to viral infection, activates both monocytes and macrophages producing a restricted panel of cytokines and therefore is an important factor in activating innate immune responses at the site of viral infection. This cytokine is produced in a serum-free, chemically defined media. Production in human 293 cells offers a |
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| Size | 10ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q8IZJ0 |
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| Catalog # | 368996 |
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| Order / More Info | IL-28A, Recombinant, Human (Interleukin-28A, IFN lambda 2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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