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| Product Name | IL28A, Recombinant, Human (Zcyto20, Interleukin-28A, Interferon Lambda-2) |
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| Description | Purity ~95% (SDS-PAGE). Interferon lambda-2, also known as Interleukin 28A, is an antiviral cytokine with immunomodulatory activity and is distantly related to the IL-10 family and type I interferons. IL28A along with IL29 and IL28B, are three closely related cytokines that form a cytokine gene cluster that use a distinct receptor system which induces antiviral defense signals. IL28A interacts with a heterodimeric class II cytokine receptor ligand and leads to the activation of the JAK/STAT signalling pathway, which ultimately leads to IFN-stimulated gene (ISG) and MHC class I antigen expression. It also plays a key role in antiviral defense in Toll-like receptors (TLR) and intestinal epithelia. Source: Recombinant protein corresponding to human IL28A expressed in E. coli. Molecular Weight: ~19.5kD Biological Activity: The ED50 is 10-50ng/ml as determined by an anti-viral assay (using human hepatocellular carcinoma cells infected with EMC virus). Endotoxin: <1EU/ug (LAL) |
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| Size | 20ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | SwissProt: Q8IZJ0 |
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| Catalog # | 500143 |
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| Order / More Info | IL28A, Recombinant, Human (Zcyto20, Interleukin-28A, Interferon Lambda-2) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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