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| Product Name | APEX1, Recombinant, Human, aa32-318, His-Tag (DNA-(Apurinic or Apyrimidinic Site) Lyase) |
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| Description | Purity ~90% (SDS-PAGE). Multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Does also incise at AP sites in the DNA strand of DNA/RNA hybrids, single-stranded DNA regions of R-loop structures, and single-stranded RNA molecules. Has a 3'-5' exoribonuclease activity on mismatched deoxyribonucleotides at the 3' termini of nicked or gapped DNA molecules during short-patch BER. Possesses a DNA 3' phosphodiesterase activity capable of removing lesions (such as phosphoglycolate) blocking the 3' |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | APEX nuclease, APEN Apurinic-apyrimidinic endonuclease 1, AP endonuclease 1, APE-1REF-1Redox factor-1 |
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| Gene, Accession, CAS # | SwissProt: P27695 |
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| Catalog # | 372287 |
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| Order / More Info | APEX1, Recombinant, Human, aa32-318, His-Tag (DNA-(Apurinic or Apyrimidinic Site) Lyase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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