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| Product Name | ADA, Bovine, Western Blot Positive Control (Adenosine Deaminase, Adenosine Aminohydrolase) |
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| Description | Adenosine deaminase (ADA; EC 3.5.4.4, human 393aa; mol wt 32-33kD, pI=4.85) catayzes deaminaiton of adenosine to inosine. ADA is found primarily in cytosol. It has also been located at the cell mmbrane and implicated in the availability of adenosine. It is ubiquitous in mammalian tissue, and deficiency in adenosine deaminase has been associated with severe combined immunodeficiency disease. The enzyme has been tested as a target for gene therapy treatments of this disease There is a common allele, ADA2, also known as the ADA 2 allozyme. It is associated with the reduced metabolism of adenosine to inosine. It specifically enhances deep sleep and slow-wave activity (SWA) during sleep. Defects in ADA are a cause of autosomal recessive severe combined immunodeficiency SCID, a congenital disorder characterized by impairment of both humoral and cell-mediated immunity, leukopenia, and low or absent antibody levels. Onset is during infancy. Less often, immune dysfunction develops later in chil |
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| Size | 100ul |
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| Concentration | n/a |
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| Applications | WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | A0870-05C |
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| Order / More Info | ADA, Bovine, Western Blot Positive Control (Adenosine Deaminase, Adenosine Aminohydrolase) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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