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| Product Name | LRRK2 Mutant (Y1699C), Active |
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| Description | 968-end (Y1699C). MW: ~210 kDa. Description: Recombinant human LRRK2 (Y1699C) (968-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.Scientific Background: LRRK2 or leucine-rich repeat kinase is a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. Mutations in LRRK2 are the most frequent known cause of autosomal dominant and idiopathi |
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| Size | 0.005 mg, 0.01 mg |
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| Concentration | n/a |
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| Applications | Kinase Assay |
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| Other Names | [Homo sapiens leucine rich repeat kinase 2 (LRRK2), mRNA; Leucine-rich repeat serine/threonine-protein kinase 2; leucine-rich repeat serine/threonine-protein kinase 2; leucine rich repeat kinase 2; Dardarin] |
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| Gene, Accession, CAS # | LRRK2, Gene ID: 120892, Accession: NM_198578.3 |
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| Catalog # | MBS515529 |
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| Order / More Info | LRRK2 Mutant (Y1699C), Active from MYBIOSOURCE INC. |
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| Product Specific References | 1. Yao C, LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease. Neurobiol Dis. 2010 Oct;40 (1):73-81. 2. Looyenga BD, Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. Proc Natl Acad Sci U S A. 2011 Jan 25;108 (4):1439-44. |
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