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| Product Name | Hmgb1, Recombinant, Human, aa2-215, His-Tag (High Mobility Group Protein B1) |
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| Description | Purity ~90% (SDS-PAGE). Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury. Released to the Extracellular domain environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activ |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | High mobility group protein 1,HMG-1 |
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| Gene, Accession, CAS # | SwissProt: P09429 |
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| Catalog # | 373651 |
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| Order / More Info | Hmgb1, Recombinant, Human, aa2-215, His-Tag (High Mobility Group Protein B1) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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