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| Product Name | Quantitative Cellular Senescence Assay |
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| Description | Background: Normal primary cells proliferate in culture for a limited number of population doublings prior to undergoing terminal growth arrest and acquiring a senescent phenotype. This finite life span correlates with the age of the organism and with the life expectancy of the species from which the cells were obtained; such that the older the age or the shorter the life span, the less the ability of the cells to undergo population doubling. Senescent cells are characterized by an irreversible |
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| Size | 10 assays, 50 assays, |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | MBS169055 |
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| Order / More Info | Quantitative Cellular Senescence Assay from MYBIOSOURCE INC. |
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| Product Specific References | 1. Current Protocols in Molecular Biology, John Wiley & Sons Press.2. Campisi, J. (2000) In Vivo 14, 183-188.3. Dimri, G. P., X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E. E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, M. Peacocke, and J. Campisi. (1995) Proc. Natl. Acad. Sci. USA 92:9363-9367.1. Kim, J. et al. (2014) p53 Induces Skin Aging by Depleting Blimp1 Sebaceous Gland Cells. Cell Death Dis. 5: e1141 2. Grasso, D. et al. (2014). Genetic Inactivation of the Pancreatitis-Inducible Gene Nupr1 Impairs PanIN Formation by Modulating Kras(G12D)-Induced Senescence. Cell Death Differ. 21:1633-1641. 3. Landowski, T. H. et al. (2014). Targeting Integrin alpha6 Stimulates Curative-Type Bone Metastasis Lesions in a Xenograft Model. Mol Cancer Ther. 13:1558-1566. |
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