| 产品详情 |
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| Product Name | H-89 Dihydrochloride |
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| Description | Purity ~99% (HPLC). A cell-permeable, selective, reversible, ATP-competitive and potent inhibitor of protein kinase A (Ki = 48nM). Inhibits other kinases only at much higher concentrations: CaM kinase II (Ki = 29.7uM), casein kinase I (Ki = 38.3uM), myosin light chain kinase (Ki = 28.3uM), protein kinase C (Ki = 31.7uM), and ROCK-II (IC50 = 270nM). May be used to discriminate between the effects of PKA and cAMP-regulated guanine-nucleotide-exchange factors (GEFs) such as GEFI, GEFII, or Epac (exchange protein directly activated by cAMP). Enhances radiation-induced apoptosis in the human cell line BM 13674. Formula: C20H20BrN3O2S · 2HCl Solubility: DMSO (200mg/ml), H2O (25mg/ml) Molecular Weight: 519.3 |
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| Size | 1mg |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | H-89 Dihydrochloride (PKA Inhibitor III, N-[2-((p-Bromocinnamyl)amino)ethyl]-5-isoquinolinesulfonamide, 2HCl) |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | 217411 |
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| Order / More Info | H-89 Dihydrochloride from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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