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| Product Name | ESR1, Recombinant, Human, aa10-595, His-Tag (Estrogen Receptor) |
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| Description | Purity ~85% (SDS-PAGE). Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B resp |
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| Size | 10ug, 50ug, 100ug |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | ER-alpha Estradiol receptor, Nuclear receptor subfamily 3 group A member 1 |
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| Gene, Accession, CAS # | SwissProt: P03372 |
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| Catalog # | 373225 |
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| Order / More Info | ESR1, Recombinant, Human, aa10-595, His-Tag (Estrogen Receptor) from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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