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| Product Name | Necrox-5 (methanesulfonate) |
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| Description | Purity >95%. Necrox-5 is a cell permeable inhibitor of necrosis that also demonstrates strong mitochondrial reactive oxygen species and ONOO- scavenging activity. It predominantly localizes in mitochondria, selectively blocking oxidative stress-induced necrotic cell death (0.1 µM necrox-5 inhibits ~50% cell death in H9C2 cells exposed to 400 µM t -BHP). This compound has been shown to protect cells from oxidative stress, hypoxia, and cold shock in vitro, as well as carbon tetrachloride-induced liver injury and chronic liver fibrosis in rodent models. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 5-[(1,1-dioxido-4-thiomorpholinyl)methyl]-2-phenyl-N-[(tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-7-amine, dimethanesulfonate, Necrosis Inhibitor 5, NecroX-5 |
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| Gene, Accession, CAS # | CAS: 1383718-29-3 |
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| Catalog # | LS-H8956 |
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| Order / More Info | Necrox-5 (methanesulfonate) from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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