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| Antigenic Specificity | Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (aa 780-830), (Cytoplasmic Domain) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rat, mouse, human |
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| Isotype | n/a |
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| Format | unconjugated |
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| Size | 500 µg |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Receptor for neurotrophin-3 (NT-3). This is a tyrosine-protein kinase receptor. Known substrates for the trk receptors are SHC1, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties.Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.Subunit: Exists in a dynamic equilibrium between monomeric (low affinity) and dimeric (high affinity) structures. Binds SH2B2. Interacts with SQSTM1 and ARMS.Subcellular location: Membrane, Single-pass type I membrane protein.Tissue specificity: Widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. Also known as: Neurotrophic tyrosine kinase receptor type 3, TrkC tyrosine kinase, GP145-TrkC, Trk-C, NT-3 growth factor receptor, NTRK3. |
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| Immunogen | A synthetic peptide from aa region 780-830 of the cytoplasmic domain of human TrkC conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and mouse. |
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| Other Names | TRKC|gp145(trkC)|AW125844|Ntrk3_tv3|TrkC|trkC |
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| Gene, Accession # | Gene ID: 4916,18213,29613 |
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| Catalog # | ABIN351089 |
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| Order / More Info | Neurotrophic tyrosine Kinase, Receptor, Type 3 (NTRK3) (aa 780-830), (Cytoplasmic Domain) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 18034455, 7806211, 1488112, 9856458, 7823156, 10388563, 8494648, 8494647 |
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