| 产品详情 |
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| Antigenic Specificity | Sortilin 1 (SORT1) (Extracellular Domain) |
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| Clone | polyclonal |
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| Host Species | Sheep |
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| Reactive Species | rat, mouse |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 µL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi.Subunit: Interacts with the cytosolic adapter proteins GGA1 and GGA2. Interacts with numerous ligands including the receptor-associated protein LRPAP1/RAP and GM2A, LPL, PSAP and SLC2A4. Forms a complex with NGFR which binds specifically to the precursor form of NGFB (proNGFB). Interacts with the precursor form of BDNF (proBDNF).Subcellular location: Membrane, Single-pass type I membrane protein. Note: Localized to membranes of the endosomes, Golgi stack, lysosomes and nucleus. Localization to the plasma membrane in adipocytes is enhanced by insulin. Localized to the endoplasmic reticulum and the plasma membrane. Also found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes.Tissue specificity: Highly expressed in fat, brain, and lung. Expressed in neuronal bodies and dendrites of the piriform cortex and hippocampus. Also expressed in the islands of Calleja, medial and lateral septal nuclei, amygdaloid nuclei, thalamic nuclei, the supraoptic nucleus, the substantia nigra, the Purkinje layer of the cerebellar cortex and the cranial motor nerve nuclei of the brainstem. Also known as: Neurotensin receptor 3, NTR3, Glycoprotein 110, Gp110, Nt3, Nts3. |
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| Immunogen | A synthetic peptide from the extracellular domain of Sortilin conjugated to blue carrier protein was used as the antigen. The peptide shares 95% identity with mouse sequence. |
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| Other Names | SORT1|19.m02079|gp95|ldlcq6|sortilin|Gp95|LDLCQ6|NT3|2900053A11Rik|AI852375|Ntr3|Ntsr3|Nt3|Nts3|sort1|zgc:85953 |
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| Gene, Accession # | Gene ID: 20661,83576 |
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| Catalog # | ABIN350869 |
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| Price | |
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| Order / More Info | Sortilin 1 (SORT1) (Extracellular Domain) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 15987945, 12771154, 15057822, 9305862, 9452485, 12746864 |
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