| 产品详情 |
| Edit |   |
|---|
| Product Name | GDC-0032 |
|---|
| Description | Purity >98%. GDC-0032 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K) isoforms Alpha, Delta, and Gamma (IC50 s = 0.28, 0.12, and 0.97 nM, respectively) that is 31 times less potent at PI3KBeta. It is over 1,000-fold selective for p100Alpha over other PI3K-like kinases, including DNA-dependent protein kinase catalytic subunits, ATM, and ATR. GDC-0032 has increased potency in cancer cell lines harboring PIK3CA-activating alterations, and is effective in vivo, suppressing the growth of tumors in a mouse xenograft model at low drug dose levels. |
|---|
| Size | n/a |
|---|
| Concentration | n/a |
|---|
| Applications | n/a |
|---|
| Other Names | 4-[5,6-dihydro-2-[3-methyl-1-(1-methylethyl)-1H-1,2,4-triazol-5-yl]imidazo[1,2-d][1,4]benzoxazepin-9-yl]-a,a-dimethyl-1H-pyrazole-1-acetamide, Taselisib |
|---|
| Gene, Accession, CAS # | CAS: 1282512-48-4 |
|---|
| Catalog # | LS-H7908 |
|---|
| Price | |
|---|
| Order / More Info | GDC-0032 from LIFESPAN BIOSCIENCES INC. |
|---|
| Product Specific References | n/a |
|---|
| 产品资料 |
|
|