| 产品详情 |
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| Product Name | GDC-0152 |
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| Description | Purity >95%. Inhibitor of apoptosis proteins (IAPs), which block various signaling pathways leading to apoptotic cell death, are commonly over-expressed in cancer cells. GDC-0152 is a potent inhibitor of specific IAPs that binds baculoviral IAP repeat (BIR) domains (Ki s = 28, 14, 17, and 43 nM for XIAP BIR3, NL-IAP BIR, BIRC2 (c-IAP1) BIR3, and BIRC3 (c-IAP2) BIR3, respectively). GDC-0152 induces activation of caspases, decreasing the viability of cancer cells without affecting normal cells. It is orally bioavailable and suppresses tumor growth in breast cancer xenografts in mice. GDC-0152 also induces NF-?B transcriptional activity, resulting in the expression of several cytokines, including TNF-Alpha. In dogs and rats, but not humans, this leads to a pronounced inflammatory response. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-N-(4-phenyl-1,2,3-thiadiazol-5-yl)-L-prolinamide |
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| Gene, Accession, CAS # | CAS: 873652-48-3 |
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| Catalog # | LS-H7907 |
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| Order / More Info | GDC-0152 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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