| 产品详情 |
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| Product Name | GDC-0449 |
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| Description | Purity >98%. Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GDC-0449 is a potent antagonist of SMO that acts in a biphasic manner, with apparent high affinity (Ki = 1.3 nM) and low affinity (Ki = 2.3 µM) binding. It suppresses Gli-mediated transcription in Calu-6 tumors with an IC50 value of 13 nM and prevents hedgehog-dependent medulloblastoma allograft growth in mice. GDC-0449 less potently inhibits the ATP-binding cassette (ABC) proteins ABCG2 and ABCB1 (IC50 = 1.4 and 3.0 µM, respectively), which may ameliorate drug resistance. This compound has potential applications in several forms of cancer, including basal cell carcinoma. |
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| Size | n/a |
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| Concentration | n/a |
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| Applications | n/a |
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| Other Names | 2-chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)-benzamide, Vismodegib |
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| Gene, Accession, CAS # | CAS: 879085-55-9 |
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| Catalog # | LS-H7910 |
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| Price | |
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| Order / More Info | GDC-0449 from LIFESPAN BIOSCIENCES INC. |
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| Product Specific References | n/a |
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