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| Product Name | MAP Kinase Pathway, p38 Antibody Sampler Kit, BioAssay™ |
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| Description | p38 MAP kinase (MAPK), also called RK (1) or CSBP (2), is the mammalian orthologue of the yeast HOG kinase that participates in a signaling cascade controlling cellular responses to cytokines and stress (1-4). Four isoforms of p38 MAP kinase, p38a B, g (also known as ERK6 or SAPK3), and d (also known as SAPK4) have been identified. Similar to the SAPK/JNK pathway, p38 MAP kinase is activated by a variety of cellular stresses including osmotic shock, inflammatory cytokines, lipopolysaccharides (LPS), UV light, and growth factors (1-5). MKK3, MKK6, and SEK activate p38 MAP kinase by phosphorylation at Thr180 and Tyr182. Activated p38 MAP kinase has been shown to phosphorylate and activate MAPKAP kinase 2 (3) and to phosphorylate the transcription factors ATF-2 (5), Max (6), and MEF2 (5-8). SB203580 (4-(4-fluorophenyl)- 2-(4-methylsulfinylphenyl)-5-(4- pyridyl)imidazole) is a selective inhibitor of p38 MAPK. This compound inhibits the activation of MAPKAPK-2 by p38 and thereby phosphoryla |
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| Size | 5x20ul |
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| Concentration | n/a |
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| Applications | IP WB |
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| Other Names | n/a |
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| Gene, Accession, CAS # | n/a |
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| Catalog # | M2352-07H |
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| Order / More Info | MAP Kinase Pathway, p38 Antibody Sampler Kit, BioAssay™ from UNITED STATES BIOLOGICAL |
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| Product Specific References | n/a |
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